Anti-Mouse IFN-gamma Recombinant Antibody (XMG1.2) (MF813013)

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1mg

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货号	MF813013
品牌	abinScience
种属反应性	Mouse
应用	FCM
同种型	IgG1, kappa
克隆号	XMG1.2
靶标	Interferon gamma, IFN-gamma, Immune interferon, IFNG
内毒素水平	< 10 EU/mg
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P01580
RRID	Anti-Mouse IFNG/IFN-gamma Antibody (XMG1.2) (abinScience Cat# MF813013, RRID:AB_3725653)
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Interferon gamma (IFNG/IFN-gamma) is a ~17 kDa protein. Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. 1. Pearl, JE. et al. (2001) Cellular immunology 211, 43-50. PMID: 11585387 2. Huang, S. et al. (1993) Science (New York, N.Y.) 259, 1742-5. PMID: 8456301 3. Baldridge, MT. et al. (2010) Nature 465, 793-7. PMID: 20535209 4. Matatall, KA. et al. (2014) Stem cells (Dayton, Ohio) 32, 3023-30. PMID: 25078851
Note	For research use only.

SDS-PAGE

SDS-PAGE for Anti-Mouse IFNG/IFN-gamma Antibody (XMG1.2).

产品说明书

Anti-Mouse IFN-gamma Recombinant Antibody (XMG1.2).pdf

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Anti-Mouse IFN-gamma Recombinant Antibody (XMG1.2) (MF813013)

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Anti-Mouse IFN-gamma Recombinant Antibody (XMG1.2) (MF813013)

概述

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参考文献

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