Anti-Mouse IL-2 Recombinant Antibody (S4B6) (MX011023)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

MX011023

abinScience

种属反应性

Mouse

ELISA, FCM

IgG2a, kappa

经测试应用

IL2, IL-2, Aldesleukin, Interleukin-2, TCGF, T-cell growth factor

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

P04351

Anti-Mouse IL2 Antibody (S4B6) (abinScience Cat# MX011023, RRID:AB_3725657)

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Interleukin-2 (IL2) is a ~19 kDa protein. Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.

1. Zhu, J. et al. (2003) Immunity 19, 739-48. PMID: 14614860

2. Reya, T. et al. (1998) Developmental immunology 5, 287-302. PMID: 9814585

3. Smith, GA. et al. (2016) Nature chemical biology 12, 373-9. PMID: 27018889

For research use only.

Isotype Control

Rat IgG2a Recombinant Isotype Control Antibody (SPE-7) (RF533107)

SDS-PAGE

SDS-PAGE for Anti-Mouse IL2 Antibody (S4B6).
Western blot

Western blot analysis was performed using anti-IL2 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant mouse IL2 (Catalog No: MX011012)
Lane 2: negative control

产品说明书

Anti-Mouse IL-2 Recombinant Antibody (S4B6).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse IL-2 Recombinant Antibody (S4B6) (MX011023)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse IL-2 Recombinant Antibody (S4B6) (MX011023)

概述

图片

参考文献

产品说明书

相关产品推荐

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