Anti-Phospho-AKT1 (pS473) Recombinant Antibody (SAA0300) (HB610013)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HB610013

abinScience

种属反应性

Human

IHC, IP, WB

IgG2a, kappa

SAA0300

RAC-alpha serine/threonine-protein kinase, RAC, RAC-PK-alpha, PKB alpha, Proto-oncogene c-Akt, Protein kinase B alpha, Protein kinase B, AKT1, PKB

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

P31749

Anti-Phospho-AKT1 (pS473) Antibody (SAA0300) (abinScience Cat# HB610013, RRID:AB_3725757)

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

RAC-alpha serine/threonine-protein kinase (p-AKT1) is a ~55 kDa protein. AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling.

1. Nicholson, KM. et al. (2002) Cellular signalling 14, 381-95. PMID: 11882383

2. Rönnstrand, L. (2004) Cellular and molecular life sciences : CMLS 61, 2535-48. PMID: 15526160

3. Cartlidge, RA. et al. (2005) The EMBO journal 24, 1696-705. PMID: 15861136

4. Heron-Milhavet, L. et al. (2011) Histology and histopathology 26, 651-62. PMID: 21432781

5. Hers, I. et al. (2011) Cellular signalling 23, 1515-27. PMID: 21620960

6. Walia, V. et al. (2019) Developmental cell 50, 229-246.e7. PMID: 31204173

7. Choppara, S. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 998-1003. PMID: 29343641

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Phospho-AKT1 (pS473) Antibody (SAA0300)

产品说明书

Anti-Phospho-AKT1 (pS473) Recombinant Antibody (SAA0300).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

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试剂盒

实验相关试剂

Anti-Phospho-AKT1 (pS473) Recombinant Antibody (SAA0300) (HB610013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Phospho-AKT1 (pS473) Recombinant Antibody (SAA0300) (HB610013)

概述

图片

参考文献

产品说明书

相关产品推荐

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