Anti-Phospho-CHK2 (pT68) Recombinant Antibody (34#) (HF505013)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HF505013

abinScience

种属反应性

Human

IHC, IP, WB

IgG2a, kappa

RAD53, CHK2 checkpoint homolog, hCds1, Serine/threonine-protein kinase Chk2, CDS1, Checkpoint kinase 2, CHEK2, Hucds1, Cds1 homolog, CHK2

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

O96017

Anti-Phospho-CHK2 (pT68) Antibody (34#) (abinScience Cat# HF505013, RRID:AB_3725761)

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Serine/threonine-protein kinase Chk2 (p-CHK2) is a ~60 kDa protein. Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression.

1. Liu, J. et al. (2023) Cell reports 42, 113402. PMID: 37943659

2. Magni, M. et al. (2014) Nucleic acids research 42, 13150-60. PMID: 25361978

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Phospho-CHK2 (pT68) Antibody (34#).

产品说明书

Anti-Phospho-CHK2 (pT68) Recombinant Antibody (34#).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

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实验相关试剂

Anti-Phospho-CHK2 (pT68) Recombinant Antibody (34#) (HF505013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Phospho-CHK2 (pT68) Recombinant Antibody (34#) (HF505013)

概述

图片

参考文献

产品说明书

相关产品推荐

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