Anti-Human CFTR Recombinant Nanobody (SAA0794) (HY313013)

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50ug
100ug
1mg

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概述
图片
参考文献
产品说明书

概述

货号

HY313013

品牌

abinScience

描述

Anti-Human CFTR Nanobody (SAA0794) [SAA0794] (HY313013) is a alpaca monoclonal antibody detecting CFTR in ELISA, FCM. Suitable for Human.

Highlights

●Flow Cytometry — Validated for flow cytometry applications.

种属反应性

Human

应用

ELISA, FCM

宿主

Alpaca

克隆类型

Monoclonal

同种型

VHH-8His-Cys-tag

克隆号

SAA0794

靶标

Cystic fibrosis transmembrane conductance regulator, Channel conductance-controlling ATPase, ABCC7, ATP-binding cassette sub-family C member 7, CFTR, cAMP-dependent chloride channel

内毒素水平

< 10 EU/mg as determined by LAL method.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Purified by Nickel column.

Accession号

P13569

状态

Liquid

保存溶液

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Cystic fibrosis transmembrane conductance regulator (CFTR) is a ~168 kDa protein. Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. In vitro, mediates ATP-dependent glutathione flux.

1. Shah, VS. et al. (2016) Science (New York, N.Y.) 351, 503-7. PMID: 26823428

2. Ostedgaard, LS. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5657-62. PMID: 10792060

3. Ramjeesingh, M. et al. (2001) Biochemistry 40, 10700-6. PMID: 11524016

4. Cheng, J. et al. (2002) The Journal of biological chemistry 277, 3520-9. PMID: 11707463

5. Hallows, KR. et al. (2003) American journal of physiology. Cell physiology 284, C1297-308. PMID: 12519745

6. Silvis, MR. et al. (2003) The Journal of biological chemistry 278, 11554-60. PMID: 12529365

7. Chappe, V. et al. (2003) The Journal of physiology 548, 39-52. PMID: 12588899

8. Kogan, I. et al. (2003) The EMBO journal 22, 1981-9. PMID: 12727866

9. Shcheynikov, N. et al. (2004) The Journal of biological chemistry 279, 21857-65. PMID: 15010471

10. Mense, M. et al. (2006) The EMBO journal 25, 4728-39. PMID: 17036051

Note

For research use only.

图片

SDS-PAGE

SDS-PAGE for Anti-Human CFTR Nanobody (SAA0794)

参考文献

产品说明书

Anti-Human CFTR Recombinant Nanobody (SAA0794).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CFTR Recombinant Nanobody (SAA0794) (HY313013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CFTR Recombinant Nanobody (SAA0794) (HY313013)

概述

图片

参考文献

产品说明书

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