Anti-Human ASIC1 Recombinant Nanobody (SAA1106) (HX873013)

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1mg

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概述
图片
参考文献
产品说明书

概述

货号

HX873013

品牌

abinScience

描述

Anti-Human ASIC1 Nanobody (SAA1106) [SAA1106] (HX873013) is a alpaca monoclonal antibody detecting ASIC1 in ELISA. Suitable for Human.

种属反应性

Human

应用

ELISA

宿主

Alpaca

克隆类型

Monoclonal

同种型

VHH-8His-Cys-tag

克隆号

SAA1106

靶标

ASIC1, Amiloride-sensitive cation channel 2, neuronal, BNaC2, Brain sodium channel 2, ACCN2, Acid-sensing ion channel 1, BNAC2

内毒素水平

< 10 EU/mg as determined by LAL method.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Purified by Nickel column.

Accession号

P78348

状态

Liquid

保存溶液

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Acid-sensing ion channel 1 (ASIC1) is a ~59 kDa protein. Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory. Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents. Displays high selectivity for sodium ions but can also permit the permeation of other cations. Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear.

1. Hoagland, EN. et al. (2010) The Journal of biological chemistry 285, 41852-62. PMID: 21036899

2. Sun, D. et al. (2020) eLife 9. PMID: 32915133

3. Wu, Y. et al. (2021) eLife 10. PMID: 34319232

Note

For research use only.

图片

SDS-PAGE

SDS-PAGE for Anti-Human ASIC1 Nanobody (SAA1106)

参考文献

产品说明书

Anti-Human ASIC1 Recombinant Nanobody (SAA1106).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ASIC1 Recombinant Nanobody (SAA1106) (HX873013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ASIC1 Recombinant Nanobody (SAA1106) (HX873013)

概述

图片

参考文献

产品说明书

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