Anti-Human Notch-2 Recombinant Nanobody (SAA1287) (HC513013)

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50ug
100ug
1mg

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概述
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参考文献
产品说明书

概述

货号

HC513013

品牌

abinScience

描述

Anti-Human NOTCH2 Nanobody (SAA1287) [SAA1287] (HC513013) is a alpaca monoclonal antibody detecting NOTCH2 in ELISA. Suitable for Human.

种属反应性

Human

应用

ELISA

宿主

Alpaca

克隆类型

Monoclonal

同种型

VHH-8His-Cys-tag

克隆号

SAA1287

靶标

N2ICD, N2ECD, NOTCH2, hN2, Neurogenic locus notch homolog protein 2, Notch 2

内毒素水平

< 10 EU/mg as determined by LAL method.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Purified by Nickel column.

Accession号

Q04721

状态

Liquid

保存溶液

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Neurogenic locus notch homolog protein 2 (NOTCH2) is a ~265 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation.

1. Simpson, MA. et al. (2011) Nature genetics 43, 303-5. PMID: 21378985

2. Isidor, B. et al. (2011) Nature genetics 43, 306-8. PMID: 21378989

3. Fukushima, H. et al. (2017) Molecular cell 68, 645-658.e5. PMID: 29149593

4. Zhu, P. et al. (2015) Nature communications 6, 7122. PMID: 25985737

Note

For research use only.

图片

SDS-PAGE

SDS-PAGE for Anti-Human NOTCH2 Nanobody (SAA1287).

参考文献

产品说明书

Anti-Human Notch-2 Recombinant Nanobody (SAA1287).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Notch-2 Recombinant Nanobody (SAA1287) (HC513013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Notch-2 Recombinant Nanobody (SAA1287) (HC513013)

概述

图片

参考文献

产品说明书

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