Anti-Human BACE2 Recombinant Nanobody (SAA1007) (HV256033)

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50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HV256033

品牌

abinScience

描述

Anti-Human BACE2 Nanobody (SAA1007) [SAA1007] (HV256033) is a alpaca monoclonal antibody detecting BACE2 in ELISA. Suitable for Human.

种属反应性

Human

应用

ELISA

宿主

Alpaca

克隆类型

Monoclonal

同种型

VHH-8His-Cys-tag

克隆号

SAA1007

靶标

Aspartyl protease 1, Membrane-associated aspartic protease 1, Beta-secretase 2, ASP21, BACE2, Asp 1, ALP56, Beta-site APP cleaving enzyme 2, Aspartic-like protease 56 kDa, Beta-site amyloid precursor protein cleaving enzyme 2, Down region aspartic protease, Theta-secretase, Memapsin-1, AEPLC, ASP1, DRAP

内毒素水平

< 10 EU/mg as determined by LAL method.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Purified by Nickel column.

Accession号

Q9Y5Z0

状态

Liquid

保存溶液

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Beta-secretase 2 (BACE2) is a ~56 kDa protein. Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus.

1. Yan, R. et al. (1999) Nature 402, 533-7. PMID: 10591213

2. Hussain, I. et al. (2000) Molecular and cellular neurosciences 16, 609-19. PMID: 11083922

3. Yan, R. et al. (2001) The Journal of biological chemistry 276, 34019-27. PMID: 11423558

4. Sun, X. et al. (2005) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19, 739-49. PMID: 15857888

5. Sun, X. et al. (2006) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20, 1369-76. PMID: 16816112

6. Rochin, L. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 10658-63. PMID: 23754390

7. Esterházy, D. et al. (2011) Cell metabolism 14, 365-77. PMID: 21907142

Note

For research use only.

图片

SDS-PAGE

SDS-PAGE for Anti-Human BACE2 Recombinant Nanobody (SAA1007)

参考文献

产品说明书

Anti-Human BACE2 Recombinant Nanobody (SAA1007).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human BACE2 Recombinant Nanobody (SAA1007) (HV256033)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human BACE2 Recombinant Nanobody (SAA1007) (HV256033)

概述

图片

参考文献

产品说明书

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