Anti-HCMV/HHV5 HHRF3/US28 Recombinant Nanobody (SAA1107) (VK595033)

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50ug
100ug
1mg

数量：

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概述
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参考文献
产品说明书

概述

货号

VK595033

品牌

abinScience

描述

Anti-HCMV/HHV5 HHRF3/US28 Nanobody (SAA1107) [SAA1107] (VK595033) is a alpaca monoclonal antibody detecting HHRF3 in ELISA.

种属反应性

Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)

应用

ELISA

宿主

Alpaca

同种型

VHH-8His-Cys-tag

克隆号

SAA1107

克隆类型

Monoclonal

靶标

G-protein coupled receptor homolog US28, HHRF3, US28

内毒素水平

Please contact with the lab for this information.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Purified by Nickel column.

Accession号

P69332

状态

Liquid

保存溶液

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

G-protein coupled receptor homolog US28 (HHRF3) is a ~41 kDa protein. Viral chemokine receptor that plays a critical role in viral pathogenesis, mediating several processes such as cellular migration, differentiation, transformation, and viral latency and reactivation. Binds to a great number of different CC-chemokines including CCL5/RANTES, CCL2/MCP-1, CCL3/MIP-1-alpha as well as CX3CL1/Fractalkine. Transduces signals resulting in the activation of MAP kinase signaling pathways and augmentation of intracellular calcium ion levels, leading to alterations in chemotactic behavior of vascular smooth muscle cells and macrophages. The US28 receptor also exhibits high levels of agonist-independent signaling activity and agonist-independent endocytosis. Interacts with the host Gi complex without activating it, thereby probably interfering with the chemokine-Gi signaling.

1. Burg, JS. et al. (2015) Science (New York, N.Y.) 347, 1113-7. PMID: 25745166

2. Kuhn, DE. et al. (1995) Biochemical and biophysical research communications 211, 325-30. PMID: 7540006

3. Gao, JL. et al. (1994) The Journal of biological chemistry 269, 28539-42. PMID: 7961796

4. Casarosa, P. et al. (2001) The Journal of biological chemistry 276, 1133-7. PMID: 11050102

5. Tsutsumi, N. et al. (2022) Science advances 8, eabl5442. PMID: 35061538

6. Maassen, F. et al. (2025) eLife 14. PMID: 40608405

Note

For research use only.

图片

SDS-PAGE

SDS-PAGE for Anti-HCMV/HHV5 HHRF3/US28 Nanobody (SAA1107)

参考文献

产品说明书

Anti-HCMV/HHV5 HHRF3/US28 Recombinant Nanobody (SAA1107).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HCMV/HHV5 HHRF3/US28 Recombinant Nanobody (SAA1107) (VK595033)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HCMV/HHV5 HHRF3/US28 Recombinant Nanobody (SAA1107) (VK595033)

概述

图片

参考文献

产品说明书

相关产品推荐

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