| 背景 | Catenin beta-1 (CTNNB1) is a ~85 kDa protein. Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Also acts as a coactivator for other transcription factors, such as NR5A2. Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes. 1. Lillehoj, EP. et al. (2007) Biochimica et biophysica acta 1773, 1028-38. PMID: 175245032. Weiske, J. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 20344-9. PMID: 180773263. Bahmanyar, S. et al. (2008) Genes & development 22, 91-105. PMID: 180868584. Li, H. et al. (2009) The Journal of biological chemistry 284, 2012-22. PMID: 189574235. Fiset, A. et al. (2011) Cellular signalling 23, 911-9. PMID: 212623536. Satow, R. et al. (2012) Gastroenterology 142, 572-81. PMID: 221551847. Genovese, G. et al. (2012) Cell cycle (Georgetown, Tex.) 11, 2206-15. PMID: 2264737810. Park, J. et al. (2018) Stem cell reports 11, 115-127. PMID: 29910125 |
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