Anti-HIV-1 Vif/SOR protein Recombinant Nanobody (SAA1421) (VK454013)

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100ug
1mg

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概述
图片
参考文献
产品说明书

概述

货号

VK454013

品牌

abinScience

描述

Anti-HIV-1 Vif/SOR protein Nanobody (SAA1421) [SAA1421] (VK454013) is a alpaca monoclonal antibody detecting SOR protein in ELISA, IP.

种属反应性

Human immunodeficiency virus type 1 (HIV-1)

应用

ELISA, IP

宿主

Alpaca

同种型

VHH-8His-Cys-tag

克隆号

SAA1421

克隆类型

Monoclonal

靶标

Virion infectivity factor, Vif, SOR protein, p17, p7, vif

内毒素水平

Please contact with the lab for this information.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Purified by Nickel column.

Accession号

P12504

状态

Liquid

保存溶液

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Virion infectivity factor (Vif/SOR protein) is a ~22 kDa protein. Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G by promoting their ubiquitination and degradation. Acts as a substrate recognition component of an E3 ubiquitin-protein ligase complex: mechanistically, Vif hijacks a host cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) and the transcription coactivator CBFB/CBF-beta to form an active E3 ubiquitin-protein ligase complex that targets APOBEC3G and APOBEC3F for polyubiquitination, leading to their degradation by the proteasome. The complex can also ubiquitinate host APOBEC3H to some extent. Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism. May interact directly with APOBEC3G mRNA in order to inhibit its translation.

Note

For research use only.

图片

SDS-PAGE

SDS-PAGE for Anti-HIV-1 Vif/SOR protein Nanobody (SAA1421)

参考文献

产品说明书

Anti-HIV-1 Vif/SOR protein Recombinant Nanobody (SAA1421).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HIV-1 Vif/SOR protein Recombinant Nanobody (SAA1421) (VK454013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HIV-1 Vif/SOR protein Recombinant Nanobody (SAA1421) (VK454013)

概述

图片

参考文献

产品说明书

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