Anti-Human TARDBP/TDP43 Recombinant Antibody (3H) (HC445013)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HC445013

abinScience

种属反应性

Human

DB, ELISA

IgG2a, kappa

TARDBP, TDP43, TAR DNA-binding protein 43, TDP-43

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

Q13148

Anti-Human TARDBP/TDP43 Antibody (3H) (abinScience Cat# HC445013, RRID:AB_3727138)

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

TAR DNA-binding protein 43 (TARDBP/TDP43) is a ~44 kDa protein. RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening.

1. Bhardwaj, A. et al. (2013) Nucleic acids research 41, 5062-74. PMID: 23519609

2. Lukavsky, PJ. et al. (2013) Nature structural & molecular biology 20, 1443-9. PMID: 24240615

3. Kuo, PH. et al. (2014) Nucleic acids research 42, 4712-22. PMID: 24464995

4. Tollervey, JR. et al. (2011) Nature neuroscience 14, 452-8. PMID: 21358640

5. Wang, A. et al. (2018) The EMBO journal 37. PMID: 29438978

6. Izumikawa, K. et al. (2017) Scientific reports 7, 7709. PMID: 28794432

7. Fukushima, M. et al. (2019) FEBS letters 593, 277-287. PMID: 30520513

8. Colombrita, C. et al. (2009) Journal of neurochemistry 111, 1051-61. PMID: 19765185

9. Higashi, S. et al. (2013) Journal of neurochemistry 126, 288-300. PMID: 23398327

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human TARDBP/TDP43 Antibody (3H)

产品说明书

Anti-Human TARDBP/TDP43 Recombinant Antibody (3H).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TARDBP/TDP43 Recombinant Antibody (3H) (HC445013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TARDBP/TDP43 Recombinant Antibody (3H) (HC445013)

概述

图片

参考文献

产品说明书

相关产品推荐

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