| 靶标 | Histone H3/j, Histone H3/b, Histone H3/d, Histone H3/c, HIST1H3B, H3FH, Histone H3/f, H3FF, H3FK, HIST1H3G, H3FL, H3FB, HIST1H3D, Histone H3/a, H3FI, Histone H3/i, H3FD, HIST1H3A, Histone H3/h, HIST1H3I, HIST1H3E, HIST1H3H, HIST1H3J, H3C1, H3FC HIST1H3C, H3FA, Histone H3.1, H3FJ, Histone H3/l, Histone H3/k, HIST1H3F |
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| 背景 | Histone H3.1 (Histone H3 trimethyl Lys27 (H3K27me3)) is a ~15 kDa protein. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
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