Anti-Human LRP5 Recombinant Antibody (SAA1526) (HF797023)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HF797023

abinScience

种属反应性

Human

ELISA

IgG2a, kappa

SAA1526

Low-density lipoprotein receptor-related protein 5, LRP5, LRP-5, LRP7, LRP-7, Low-density lipoprotein receptor-related protein 7, LR3

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

O75197

Anti-Human LRP5 Antibody (SAA1526) (abinScience Cat# HF797023, RRID:AB_3727287)

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Low-density lipoprotein receptor-related protein 5 (LRP5) is a ~179 kDa protein. Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs.

1. Mao, J. et al. (2001) Molecular cell 7, 801-9. PMID: 11336703

2. Semënov, MV. et al. (2001) Current biology : CB 11, 951-61. PMID: 11448771

3. Gong, Y. et al. (2001) Cell 107, 513-23. PMID: 11719191

4. Li, X. et al. (2005) The Journal of biological chemistry 280, 19883-7. PMID: 15778503

5. Semënov, M. et al. (2005) The Journal of biological chemistry 280, 26770-5. PMID: 15908424

6. Ai, M. et al. (2005) American journal of human genetics 77, 741-53. PMID: 16252235

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human LRP5 Antibody (SAA1526)

产品说明书

Anti-Human LRP5 Recombinant Antibody (SAA1526).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human LRP5 Recombinant Antibody (SAA1526) (HF797023)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human LRP5 Recombinant Antibody (SAA1526) (HF797023)

概述

图片

参考文献

产品说明书

相关产品推荐

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