Anti-Human CD316/IGSF8 Recombinant Antibody (SAA1612) (HV379013)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HV379013

abinScience

种属反应性

Human

ELISA

IgG2a, kappa

SAA1612

EWI2, IGSF8, CD316, Glu-Trp-Ile EWI motif-containing protein 2, Keratinocytes-associated transmembrane protein 4, LIR-D1, Prostaglandin regulatory-like protein, CD81P3, EWI-2, KCT-4, CD81 partner 3, Immunoglobulin superfamily member 8, IgSF8, KCT4, PGRL

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

Q969P0

Anti-Human CD316/IGSF8 Antibody (SAA1612) (abinScience Cat# HV379013, RRID:AB_3727373)

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Immunoglobulin superfamily member 8 (CD316/IGSF8) is a ~65 kDa protein. Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity. Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities. In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation. Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry.

1. Stipp, CS. et al. (2001) The Journal of biological chemistry 276, 40545-54. PMID: 11504738

2. Stipp, CS. et al. (2003) The Journal of cell biology 163, 1167-77. PMID: 14662754

3. Kettner, S. et al. (2007) Molecular and cellular biology 27, 7718-26. PMID: 17785435

4. Gordón-Alonso, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 689-700. PMID: 22689882

5. Potel, J. et al. (2013) Cellular microbiology 15, 1234-52. PMID: 23351194

6. Whitaker, EE. et al. (2019) Viruses 11. PMID: 31757023

7. Li, Y. et al. (2024) Cell 187, 2703-2716.e23. PMID: 38657602

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human CD316/IGSF8 Antibody (SAA1612)

产品说明书

Anti-Human CD316/IGSF8 Recombinant Antibody (SAA1612).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CD316/IGSF8 Recombinant Antibody (SAA1612) (HV379013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CD316/IGSF8 Recombinant Antibody (SAA1612) (HV379013)

概述

图片

参考文献

产品说明书

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