CD82 antigen is a ~29 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Acts as a attenuator of EGF signaling, facilitating ligand-induced endocytosis of the receptor and its subsequent desensitization. Mechanistically, modulates ligand-induced ubiquitination and trafficking of EGFR via E3 ligase CBL phosphorylation by PKC. Increases cell-matrix adhesion by regulating the membrane organization of integrin alpha4/ITA4. 1. Xu, C. et al. (2009) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 3273-88. PMID: 194979832. Odintsova, E. et al. (2000) Current biology : CB 10, 1009-12. PMID: 109853913. Bu, J. et al. (2022) Acta biochimica et biophysica Sinica 54, 400-408. PMID: 355380334. Odintsova, E. et al. (2013) The Journal of biological chemistry 288, 26323-26334. PMID: 238978135. Termini, CM. et al. (2014) Molecular biology of the cell 25, 1560-73. PMID: 246237216. Mannion, BA. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 157, 2039-47. PMID: 87573257. He, B. et al. (2005) The Journal of biological chemistry 280, 3346-54. PMID: 155572828. Jee, BK. et al. (2007) Biochemical and biophysical research communications 359, 703-8. PMID: 175605489. Bass, R. et al. (2005) The Journal of biological chemistry 280, 14811-8. PMID: 15677461 | 
