

| 货号 | HV483013 | ||||
|---|---|---|---|---|---|
| 品牌 | abinScience | ||||
| 种属反应性 | Human | ||||
| 应用 | ELISA | ||||
| 同种型 | IgG2a, kappa | ||||
| 克隆号 | SAA1700 | ||||
| 靶标 | HLC-10, E3 ubiquitin-protein transferase MAEA, Erythroblast macrophage protein, Cell proliferation-inducing gene 5 protein, P44EMLP, MAEA, Human lung cancer oncogene 10 protein, EMP, Macrophage erythroblast attacher | ||||
| 内毒素水平 | Please contact with the lab for this information. | ||||
| 纯度 | >95% as determined by SDS-PAGE. | ||||
| 纯化方式 | Protein A/G purified from cell culture supernatant. | ||||
| Accession号 | Q7L5Y9 | ||||
| RRID | Anti-Human MAEA Antibody (SAA1700) (abinScience Cat# HV483013, RRID:AB_3727461) | ||||
| 状态 | Liquid | ||||
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | E3 ubiquitin-protein transferase MAEA is a ~45 kDa protein. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages. 1. Lampert, F. et al. (2018) eLife 7. PMID: 29911972 2. Hanspal, M. et al. (1998) Blood 92, 2940-50. PMID: 9763581 | ||||
| Note | For research use only. |

SDS-PAGE for Anti-Human MAEA Antibody (SAA1700)



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