Presenilin-1 (PSEN1) is a ~52 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. 3. Ray, WJ. et al. (1999) The Journal of biological chemistry 274, 36801-7. PMID: 105939904. Kulic, L. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5913-8. PMID: 108118835. Berezovska, O. et al. (2000) Journal of neurochemistry 75, 583-93. PMID: 108999336. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 126797847. Kimberly, WT. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 6382-7. PMID: 127404398. Fraering, PC. et al. (2004) Biochemistry 43, 9774-89. PMID: 152746329. Heilig, EA. et al. (2010) The Journal of biological chemistry 285, 22350-9. PMID: 20460383 | 
