Anti-Human SCN5A Recombinant Antibody (SAA1835) (HC664013)

Anti-Human SCN5A Antibody (SAA1835) (abinScience Cat# HC664013, RRID:AB_3727598)
_x005F_x000D_ Copy Citation

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Sodium channel protein type 5 subunit alpha (SCN5A) is a ~226 kDa protein. Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat.