Anti-Human C9orf72 Recombinant Antibody (SAA1886) (HA376013)

价格:

规格：

50ug
100ug
1mg

数量：

一键复制产品信息

概述
图片
参考文献
产品说明书

HA376013

abinScience

种属反应性

Human

ELISA

Mouse

Monoclonal

IgG2a, kappa

SAA1886

Guanine nucleotide exchange C9orf72, C9orf72

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

Q96LT7

Anti-Human C9orf72 Antibody (SAA1886) (abinScience Cat# HA376013, RRID:AB_3727650)
_x005F_x000D_

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Guanine nucleotide exchange factor C9orf72 is a ~54 kDa protein. Acts as a guanine-nucleotide releasing factor (GEF) for Rab GTPases by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP. Acts as a GEF for RAB39A which enables HOPS-mediated autophagosome-lysosome membrane tethering and fusion in mammalian autophagy. Component of the C9orf72-SMCR8 complex where both subunits display GEF activity and that regulates autophagy. As part of the C9orf72-SMCR8-WDR41 (CSW) complex, functions as GEF for RAB8A and RAB39B, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, also functions as GTPase activating protein (GAP) for RAB8A and RAB11A in vitro.

1. Sellier, C. et al. (2016) The EMBO journal 35, 1276-97. PMID: 27103069

2. Sullivan, PM. et al. (2016) Acta neuropathologica communications 4, 51. PMID: 27193190

3. Yang, M. et al. (2016) Science advances 2, e1601167. PMID: 27617292

4. Jung, J. et al. (2017) eLife 6. PMID: 28195531

5. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human C9orf72 Antibody (SAA1886)

产品说明书

Anti-Human C9orf72 Recombinant Antibody (SAA1886).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human C9orf72 Recombinant Antibody (SAA1886) (HA376013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human C9orf72 Recombinant Antibody (SAA1886) (HA376013)

概述

图片

参考文献

产品说明书

相关产品推荐

获取报价