Anti-Human KARS1/Lysyl-tRNA synthetase Recombinant Antibody (SAA1945) (HC295013)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HC295013

abinScience

种属反应性

Human

ELISA

IgG2a, kappa

SAA1945

KIAA0070, KARS, Lysyl-tRNA synthetase, LysRS, Lysine--tRNA ligase, KARS1

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

Q15046

Anti-Human KARS1/Lysyl-tRNA synthetase Antibody (SAA1945) (abinScience Cat# HC295013, RRID:AB_3727709)
_x005F_x000D_

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Lysine--tRNA ligase (KARS1) is a ~68 kDa protein. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity.

1. Guzzo, CM. et al. (2008) Biochemical and biophysical research communications 365, 718-23. PMID: 18029264

2. Guo, M. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 2331-6. PMID: 18272479

3. Shiba, K. et al. (1997) The Journal of biological chemistry 272, 22809-16. PMID: 9278442

4. Park, SG. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 6356-61. PMID: 15851690

5. Lee, YN. et al. (2004) Immunity 20, 145-51. PMID: 14975237

6. Yannay-Cohen, N. et al. (2009) Molecular cell 34, 603-11. PMID: 19524539

7. Ofir-Birin, Y. et al. (2013) Molecular cell 49, 30-42. PMID: 23159739

8. Zamecnik, PC. et al. (1966) Biochemical and biophysical research communications 24, 91-7. PMID: 5338216

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human KARS1/Lysyl-tRNA synthetase Antibody (SAA1945)

产品说明书

Anti-Human KARS1/Lysyl-tRNA synthetase Recombinant Antibody (SAA1945).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human KARS1/Lysyl-tRNA synthetase Recombinant Antibody (SAA1945) (HC295013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human KARS1/Lysyl-tRNA synthetase Recombinant Antibody (SAA1945) (HC295013)

概述

图片

参考文献

产品说明书

相关产品推荐

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