Anti-Human F2R/PAR1 Recombinant Antibody (SAA1955) (HB844013)

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规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HB844013

abinScience

种属反应性

Human

ELISA

Mouse

Monoclonal

IgG2a, kappa

SAA1955

Proteinase-activated receptor 1, PAR-1, PAR1, CF2R, Coagulation factor II receptor, Thrombin receptor, F2R, TR

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

P25116

Anti-Human F2R/PAR1 Antibody (SAA1955) (abinScience Cat# HB844013, RRID:AB_3727719)
_x005F_x000D_

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Proteinase-activated receptor 1 (F2R/PAR1) is a ~47 kDa protein. High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores. The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) which binds to InsP3 receptors causing calcium release from the stores. In astrocytes, the calcium released into the cytosol allows the Ca(2+)-dependent release of L-glutamate into the synaptic cleft through BEST1, that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation. May play a role in platelets activation and in vascular development. Mediates up-regulation of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, triggered by coagulation factor Xa (F10) in cardiac fibroblasts and umbilical vein endothelial cells.

1. Vu, TK. et al. (1991) Cell 64, 1057-68. PMID: 1672265

2. Mathews, II. et al. (1994) Biochemistry 33, 3266-79. PMID: 8136362

3. Kahn, ML. et al. (1999) The Journal of clinical investigation 103, 879-87. PMID: 10079109

4. Shinozawa, E. et al. (2018) Frontiers in pharmacology 9, 1431. PMID: 30568593

5. D'Alessandro, E. et al. (2021) Cells 10. PMID: 34831181

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human F2R/PAR1 Antibody (SAA1955)

产品说明书

Anti-Human F2R/PAR1 Recombinant Antibody (SAA1955).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human F2R/PAR1 Recombinant Antibody (SAA1955) (HB844013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human F2R/PAR1 Recombinant Antibody (SAA1955) (HB844013)

概述

图片

参考文献

产品说明书

相关产品推荐

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