Anti-Human SMO/Smoothened Recombinant Antibody (SAA1978) (HV714013)

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规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HV714013

abinScience

种属反应性

Human

ELISA

IgG2a, kappa

SAA1978

SMOH, Smoothened homolog, SMO, Protein Gx

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

Q99835

Anti-Human SMO/Smoothened Antibody (SAA1978) (abinScience Cat# HV714013, RRID:AB_3727742)
_x005F_x000D_

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Protein smoothened is a ~86 kDa protein. G protein-coupled receptor which associates with the patched protein (PTCH) to transduce hedgehog protein signaling. Binding of sonic hedgehog (SHH) to its receptor patched prevents inhibition of smoothened (SMO) by patched. When active, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors which releases the GLI proteins from PRKACA-mediated inhibition and allows for transcriptional activation of hedgehog pathway target genes. Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation.

1. Endoh-Yamagami, S. et al. (2009) Current biology : CB 19, 1320-6. PMID: 19592253

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human SMO/Smoothened Antibody (SAA1978)

产品说明书

Anti-Human SMO/Smoothened Recombinant Antibody (SAA1978).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SMO/Smoothened Recombinant Antibody (SAA1978) (HV714013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SMO/Smoothened Recombinant Antibody (SAA1978) (HV714013)

概述

图片

参考文献

产品说明书

相关产品推荐

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