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Anti-Kv1.2 K+ channel Recombinant Antibody (L76/36) (HB859023)

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规格:
  • 50ug
  • 100ug
  • 1mg
数量:
  • 概述

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概述
货号HB859023
品牌abinScience
应用IHC, WB
宿主Mouse
克隆类型Monoclonal
同种型IgG2a, kappa
克隆号L76/36
靶标Voltage-gated K(+) channel HuKIV, Voltage-gated potassium channel subunit Kv1.2, NGK1, KCNA2, Potassium voltage-gated channel subfamily A member 2, Voltage-gated potassium channel HBK5
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P16389
RRID

Anti-Kv1.2 K+ channel Antibody (L76/36) (abinScience Cat# HB859023, RRID:AB_3728140)
_x005F_x000D_

状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息
应用方法 稀释比例
WB 1:500-1:2000
稳定性和存储Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景

Potassium voltage-gated channel subfamily A member 2 (KCNA2/Kv1.2 K+ channel) is a ~56 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel.

1. Imbrici, P. et al. (2000) Pflugers Archiv : European journal of physiology 441, 257-62. PMID: 11211111
2. Ramaswami, M. et al. (1990) Molecular and cellular neurosciences 1, 214-23. PMID: 19912772
3. Lee, JH. et al. (2013) Neuroscience letters 548, 143-8. PMID: 23769686
4. Po, S. et al. (1993) Circulation research 72, 1326-36. PMID: 8495559
5. Chen, P. et al. (2010) The Journal of biological chemistry 285, 14882-14889. PMID: 20220134
NoteFor research use only.
图片
  • SDS-PAGE

    SDS-PAGE for Anti-Kv1.2 K+ channel Antibody (L76/36)

参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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