Anti-Sahara scorpion AaH II/Neurotoxin II Recombinant Antibody (4C1) (ZA079013)

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规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

ZA079013

abinScience

种属反应性

Androctonus australis (Sahara scorpion)

ELISA

IgG2a

Alpha-mammal toxin AaH2, AaHII, Neurotoxin 2, Neurotoxin II

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

P01484

Anti-Sahara scorpion AaH II/Neurotoxin II Antibody (4C1) (abinScience Cat# ZA079013, RRID:AB_3728994)
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Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alpha-mammal toxin AaH2 (AaH II/Neurotoxin II) is a ~9 kDa protein. Alpha toxin that binds voltage-independently at site-3 of sodium channels (Nav), inhibits the inactivation of the activated channels, and weakly inhibits activation, thereby blocking neuronal transmission. Inserts into voltage-sensing domain IV to stabilize a deactivated state, thereby preventing fast-inactivation. Principally slows the inactivation process of TTX-sensitive sodium channels. It is active on mammalian brain Nav1.2/SCN2A (EC(50)human=0.72 nM, EC(50)rat=2.6 nM), on rat skeletal muscle Nav1.4/SCN4A (EC(50)=2.2 nM), and on human neuronal Nav1.7/SCN9A (EC(50)=6.8-51.7 nM). In vivo, intraplantar injection into mice induces spontaneous pain responses.

1. Clairfeuille, T. et al. (2019) Science (New York, N.Y.) 363. PMID: 30733386

2. Abbas, N. et al. (2013) Pain 154, 1204-15. PMID: 23685008

3. Alami, M. et al. (2003) The Biochemical journal 375, 551-60. PMID: 12911331

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Sahara scorpion AaH II/Neurotoxin II Antibody (4C1)

产品说明书

Anti-Sahara scorpion AaH II/Neurotoxin II Recombinant Antibody (4C1).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

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实验相关试剂

Anti-Sahara scorpion AaH II/Neurotoxin II Recombinant Antibody (4C1) (ZA079013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Sahara scorpion AaH II/Neurotoxin II Recombinant Antibody (4C1) (ZA079013)

概述

图片

参考文献

产品说明书

相关产品推荐

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