Anti-Human Fc gamma RIIIA/CD16a Recombinant Nanobody (SAA2051) (HY386013)
概述
图片
参考文献
产品说明书
概述
货号
HY386013
品牌
abinScience
描述
Anti-Human CD16a/FCGR3A Nanobody (SAA2051) [SAA2051] (HY386013) is a alpaca monoclonal antibody detecting FCGR3A in ELISA, FCM. Suitable for Human and Cynomolgus.
Highlights
●Flow Cytometry — Validated for flow cytometry applications.
种属反应性
Human, Monkey
应用
ELISA, FCM
宿主
Alpaca
同种型
VHH-8His-Cys-tag
克隆号
SAA2051
克隆类型
Monoclonal
靶标
CD16a, CD16A, FCGR3A, Fc-gamma RIII-alpha, FcRIIIa, IgG Fc receptor III-2, Low affinity immunoglobulin gamma Fc region receptor III-A, IGFR3, CD16a antigen, Fc-gamma RIII, FCGR3, Fc-gamma RIIIa, FCG3, FcRIII, FcR-10
内毒素水平
Please contact with the lab for this information.
纯度
>95% as determined by SDS-PAGE.
纯化方式
Purified by Nickel column.
Accession号
P08637
状态
Liquid
保存溶液
0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
产品使用信息
应用方法
稀释比例
ELISA
1:2000-1:20000
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Low affinity immunoglobulin gamma Fc region receptor III-A (CD16a/FCGR3A) is a ~29 kDa protein. Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger. Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation.
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