| 背景 | Triggering receptor expressed on myeloid cells 2 (TREM2) is a ~24 kDa protein. Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin. 1. Daws, MR. et al. (2001) European journal of immunology 31, 783-91. PMID: 112412834. Zheng, H. et al. (2017) The Journal of neuroscience : the official journal of the Society for Neuroscience 37, 1772-1784. PMID: 280777245. Kleinberger, G. et al. (2014) Science translational medicine 6, 243ra86. PMID: 249908816. Takahashi, K. et al. (2005) The Journal of experimental medicine 201, 647-57. PMID: 157282417. Cantoni, C. et al. (2015) Acta neuropathologica 129, 429-47. PMID: 256311249. Filipello, F. et al. (2018) Immunity 48, 979-991.e8. PMID: 29752066 |
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