Anti-Human CBX3 Recombinant Antibody (P003) (HC291023)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HC291023

abinScience

种属反应性

Human

ELISA, IF, IP

IgG2a

CBX3, Chromobox protein homolog 3, HECH, Heterochromatin protein 1 homolog gamma, HP1 gamma, Modifier 2 protein

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

Q13185

Anti-Human CBX3 Antibody (P003) (abinScience Cat# HC291023, RRID:AB_3729485)

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Chromobox protein homolog 3 (CBX3) is a ~20 kDa protein. Component of heterochromatin, which recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

1. Lachner, M. et al. (2001) Nature 410, 116-20. PMID: 11242053

2. Daujat, S. et al. (2005) The Journal of biological chemistry 280, 38090-5. PMID: 16127177

3. Obuse, C. et al. (2004) Nature cell biology 6, 1135-41. PMID: 15502821

4. Bot, C. et al. (2017) Journal of cell science 130, 1134-1146. PMID: 28167679

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human CBX3 Antibody (P003)

产品说明书

Anti-Human CBX3 Recombinant Antibody (P003).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CBX3 Recombinant Antibody (P003) (HC291023)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CBX3 Recombinant Antibody (P003) (HC291023)

概述

图片

参考文献

产品说明书

相关产品推荐

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