Anti-Human R-Spondin 2 Recombinant Antibody (h130M23-H1L2) (HA089033)

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100ug
1mg

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货号	HA089033
品牌	abinScience
种属反应性	Human, Mouse
应用	Blocking, in vitro, in vivo, SPR
宿主	Mouse
克隆类型	Monoclonal
同种型	IgG2a, kappa
克隆号	h130M23-H1L2
靶标	Roof plate-specific spondin-2, R-spondin-2, hRspo2, RSPO2
内毒素水平	< 10 EU/mg
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q6UXX9
RRID	Anti-Human RSPO2 Recombinant Antibody (h130M23-H1L2) (abinScience Cat# HA089033, RRID:AB_3729850)
状态	Liquid
保存溶液	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	R-spondin-2 (RSPO2) is a ~28 kDa protein. Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form. 1. de Lau, W. et al. (2011) Nature 476, 293-7. PMID: 21727895 2. Glinka, A. et al. (2011) EMBO reports 12, 1055-61. PMID: 21909076 3. Gong, X. et al. (2012) PloS one 7, e37137. PMID: 22615920 4. Szenker-Ravi, E. et al. (2018) Nature 557, 564-569. PMID: 29769720
Note	For research use only.
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

SDS-PAGE

SDS-PAGE for Anti-Human RSPO2 Recombinant Antibody (h130M23-H1L2)

产品说明书

Anti-Human R-Spondin 2 Recombinant Antibody (h130M23-H1L2).pdf

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Anti-Human R-Spondin 2 Recombinant Antibody (h130M23-H1L2) (HA089033)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human R-Spondin 2 Recombinant Antibody (h130M23-H1L2) (HA089033)

概述

图片

参考文献

产品说明书

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