Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody (MA497014)

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概述
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产品说明书

概述

货号

MA497014

品牌

abinScience

描述

Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody (MA497014) is a rabbit polyclonal antibody detecting MAG/Myelin-associated glycoprotein in ELISA, IHC, WB. Suitable for Rattus norvegicus, Human, and Mus musculus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Mouse MAG/Myelin-associated glycoprotein (Asp235-Glu410).

靶标

MAG/Myelin-associated glycoprotein

纯化方式

Purified by antigen affinity column.

Accession号

P20917

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

别名

Myelin-associated glycoprotein, Siglec-4a, Mag

背景

Myelin-associated glycoprotein (MAG) is a ~69 kDa protein. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane. Negative regulator of neurite outgrowth that inhibits axon longitudinal growth.

1. Liu, BP. et al. (2002) Science (New York, N.Y.) 297, 1190-3. PMID: 12089450

2. Pronker, MF. et al. (2016) Nature communications 7, 13584. PMID: 27922006

3. Kelm, S. et al. (1994) Current biology : CB 4, 965-72. PMID: 7533044

4. Schachner, M. et al. (2000) Glia 29, 154-65. PMID: 10625334

5. Li, C. et al. (1994) Nature 369, 747-50. PMID: 7516497

6. Bartsch, S. et al. (1997) Brain research 762, 231-4. PMID: 9262180

7. Li, C. et al. (1998) Journal of neuroscience research 51, 210-7. PMID: 9469574

8. Yin, X. et al. (1998) The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 1953-62. PMID: 9482781

9. Fujita, N. et al. (1998) The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 1970-8. PMID: 9482783

10. Palandri, A. et al. (2015) Cell death & disease 6, e1876. PMID: 26335717

Note

For research use only.

图片

参考文献

产品说明书

Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

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Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody (MA497014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody (MA497014)

概述

图片

参考文献

产品说明书

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