Anti-Human AUP1 Polyclonal Antibody (HV444014)

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概述
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参考文献
产品说明书

概述

货号

HV444014

品牌

abinScience

描述

Anti-Human AUP1 Polyclonal Antibody (HV444014) is a rabbit polyclonal antibody detecting AUP1 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Mus musculus, and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human AUP1 (Val201-Asp410).

靶标

AUP1

纯化方式

Purified by antigen affinity column.

Accession号

Q9Y679

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

别名

Lipid droplet-regulating VLDL assembly factor AUP1, Ancient ubiquitous protein 1, AUP1

背景

Lipid droplet-regulating VLDL assembly factor AUP1 is a ~45 kDa protein. Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering. Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation. Also required for the degradation of INSIG1, SREBF1 and SREBF2.

1. Mueller, B. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 12325-30. PMID: 18711132

2. Klemm, EJ. et al. (2011) The Journal of biological chemistry 286, 37602-14. PMID: 21857022

3. Lohmann, D. et al. (2013) PloS one 8, e72453. PMID: 24039768

4. Spandl, J. et al. (2011) The Journal of biological chemistry 286, 5599-606. PMID: 21127063

5. Jo, Y. et al. (2013) Molecular biology of the cell 24, 169-83. PMID: 23223569

6. Zhang, J. et al. (2017) Arteriosclerosis, thrombosis, and vascular biology 37, 633-642. PMID: 28183703

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human AUP1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human AUP1 Polyclonal Antibody (HV444014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human AUP1 Polyclonal Antibody (HV444014)

概述

图片

参考文献

产品说明书

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