

| 货号 | HB615034 | ||||||||
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| 品牌 | abinScience | ||||||||
| 描述 |
Anti-Human CD59 Polyclonal Antibody (HB615034) is a rabbit polyclonal antibody detecting CD59 in ELISA, IHC, WB. Suitable for Pongo abelii and Human.
Highlights
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| 种属反应性 | Human | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CD59 (Ser25-Pro128). | ||||||||
| 靶标 | CD59 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | P13987 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 别名 | CD59 glycoprotein, 1F5 antigen, 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-inhibitory protein, MAC-IP, MEM43 antigen, Membrane attack complex inhibition factor, MACIF, Membrane inhibitor of reactive lysis, MIRL, Protectin, CD59, CD59, MIC11, MIN1, MIN2, MIN3, MSK21 | ||||||||
| 背景 | CD59 glycoprotein is a ~14 kDa protein. Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. 1. Farkas, I. et al. (2002) The Journal of physiology 539, 537-45. PMID: 11882685 2. Meri, S. et al. (1990) Immunology 71, 1-9. PMID: 1698710 3. Okada, H. et al. (1989) Biochemical and biophysical research communications 162, 1553-9. PMID: 2475111 4. Davies, A. et al. (1989) The Journal of experimental medicine 170, 637-54. PMID: 2475570 5. Sugita, Y. et al. (1989) Journal of biochemistry 106, 555-7. PMID: 2606909 6. Bodian, DL. et al. (1997) The Journal of experimental medicine 185, 507-16. PMID: 9053451 7. Couves, EC. et al. (2023) Nature communications 14, 890. PMID: 36797260 | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-CD59 polyclonal antibody at 1ug/mL on various samples.
Lane 1: MDA-MB-231 cell lysate
Lane 2: BxPC-3 cell lysate
Lane 3: HT-29 cell lysate
Lane 4: HUVEC cell lysate



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