Anti-Mouse IFNAR2 Polyclonal Antibody (MW716014)

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100ug

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概述
图片
参考文献
产品说明书

概述

货号

MW716014

品牌

abinScience

描述

Anti-Mouse IFNAR2 Polyclonal Antibody (MW716014) is a rabbit polyclonal antibody detecting IFNAR2 in ELISA, IHC, WB. Suitable for Mus musculus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Mouse IFNAR2 (Thr40-Gln231).

靶标

IFNAR2

纯化方式

Purified by antigen affinity column.

Accession号

O35664

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

别名

Ifnar2 protein, Type I interferon alpha/beta receptor 2a, Ifnar2

背景

Interferon alpha/beta receptor 2 (IFNAR2) is a ~56 kDa protein. Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes.

Note

For research use only.

图片

Western blot

Western blot analysis was performed using anti-IFNAR2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: K562 cell lysate
Lane 2: HepG2 cell lysate

参考文献

产品说明书

Anti-Mouse IFNAR2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse IFNAR2 Polyclonal Antibody (MW716014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse IFNAR2 Polyclonal Antibody (MW716014)

概述

图片

参考文献

产品说明书

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