| 别名 | E3 ubiquitin-protein ligase AMFR, 2.3.2.36, Autocrine motility factor receptor, AMF receptor, RING finger protein 45, gp78, AMFR, RNF45 |
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| 背景 | E3 ubiquitin-protein ligase AMFR is a ~72 kDa protein. E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination. The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction. 1. Shimizu, K. et al. (1999) FEBS letters 456, 295-300. PMID: 104563272. Fang, S. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 14422-7. PMID: 117249343. Liang, JS. et al. (2003) The Journal of biological chemistry 278, 23984-8. PMID: 126709404. Pabarcus, MK. et al. (2009) Archives of biochemistry and biophysics 483, 66-74. PMID: 191031486. Wang, YJ. et al. (2017) Nature cell biology 19, 808-819. PMID: 286046769. Jo, Y. et al. (2013) Molecular biology of the cell 24, 169-83. PMID: 23223569 |
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