Anti-Human NPC1L1 Polyclonal Antibody (HP159014)

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概述
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参考文献
产品说明书

概述

货号

HP159014

品牌

abinScience

描述

Anti-Human NPC1L1 Polyclonal Antibody (HP159014) is a rabbit polyclonal antibody detecting NPC1L1 in ELISA, IHC, WB. Suitable for Rattus norvegicus and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human NPC1L1 (Arg450-Ser620).

靶标

NPC1L1

纯化方式

Purified by antigen affinity column.

Accession号

Q9UHC9

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

别名

NPC1-like intracellular cholesterol transporter 1, NPC1L1, Niemann-Pick C1-like protein 1, NPC1L1

背景

NPC1-like intracellular cholesterol transporter 1 (NPC1L1) is a ~148 kDa protein. Plays a major role in cholesterol homeostasis. Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia. May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation.

1. Yamanashi, Y. et al. (2012) Hepatology (Baltimore, Md.) 55, 953-64. PMID: 22095670

2. Garcia-Calvo, M. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8132-7. PMID: 15928087

3. Davies, JP. et al. (2005) The Journal of biological chemistry 280, 12710-20. PMID: 15671032

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human NPC1L1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human NPC1L1 Polyclonal Antibody (HP159014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human NPC1L1 Polyclonal Antibody (HP159014)

概述

图片

参考文献

产品说明书

相关产品推荐

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