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Anti-CD254/RANKL/TNFSF11 Polyclonal Antibody (PTX18516)

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概述
货号PTX18516
品牌ProteoGenix
描述
Anti-CD254/RANKL/TNFSF11 Polyclonal Antibody (PTX18516) is a rabbit polyclonal antibody detecting ODF,TNF-related activation-induced cytokine,Osteoclast differentiation factor,TNFSF11,TRANCE,Osteoprotegerin ligand,RANKL,Tumor necrosis factor ligand superfamily member 11,Receptor activator of nuclear factor kappa-B ligand,CD254,OPGL in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CD254/RANKL/TNFSF11 (Tyr69-Asp317).
靶标ODF,TNF-related activation-induced cytokine,Osteoclast differentiation factor,TNFSF11,TRANCE,Osteoprotegerin ligand,RANKL,Tumor necrosis factor ligand superfamily member 11,Receptor activator of nuclear factor kappa-B ligand,CD254,OPGL
纯化方式Purified by antigen affinity column.
Accession号O14788
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Tumor necrosis factor ligand superfamily member 11 (CD254/RANKL) is a ~35 kDa protein. Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. CD254 is the therapeutic target of denosumab (Prolia).

1. Luan, X. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 245-52. PMID: 22664871
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-CD254/RANKL/TNFSF11 Polyclonal Antibody

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