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Anti-SUV39H1 Polyclonal Antibody (PTX19458)

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概述
货号PTX19458
品牌ProteoGenix
描述
Anti-SUV39H1 Polyclonal Antibody (PTX19458) is a rabbit polyclonal antibody detecting Position-effect variegation 3-9 homolog,SUV39H,H3-K9-HMTase 1,SUV39H1,Histone-lysine N-methyltransferase SUV39H1,Su(var)3-9 homolog 1,Lysine N-methyltransferase 1A,Histone H3-K9 methyltransferase 1,Suppressor of variegation 3-9 homolog 1,KMT1A in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human SUV39H1 (Gly7-Met271).
靶标Position-effect variegation 3-9 homolog,SUV39H,H3-K9-HMTase 1,SUV39H1,Histone-lysine N-methyltransferase SUV39H1,Su(var)3-9 homolog 1,Lysine N-methyltransferase 1A,Histone H3-K9 methyltransferase 1,Suppressor of variegation 3-9 homolog 1,KMT1A
纯化方式Purified by antigen affinity column.
Accession号O43463
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Histone-lysine N-methyltransferase SUV39H1 is a ~47 kDa protein. Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats.

1. Rea, S. et al. (2000) Nature 406, 593-9. PMID: 10949293
2. Lachner, M. et al. (2001) Nature 410, 116-20. PMID: 11242053
3. Vaquero, A. et al. (2007) Nature 450, 440-4. PMID: 18004385
4. Zhou, L. et al. (2025) Science (New York, N.Y.) 389, 309-316. PMID: 40440427
5. Nielsen, SJ. et al. (2001) Nature 412, 561-5. PMID: 11484059
6. Ait-Si-Ali, S. et al. (2004) The EMBO journal 23, 605-15. PMID: 14765126
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-SUV39H1 Polyclonal Antibody

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