

| 货号 | PTX19460 |
|---|---|
| 品牌 | ProteoGenix |
| 描述 |
Anti-PRKAB2 Polyclonal Antibody (PTX19460) is a rabbit polyclonal antibody detecting AMPK subunit beta-2,PRKAB2,5'-AMP-activated protein kinase subunit beta-2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
|
| 种属反应性 | Human, Mouse, Rat |
| 应用 | ELISA, IHC, WB |
| 宿主 | Rabbit |
| 同种型 | IgG |
| 克隆类型 | Polyclonal |
| 免疫原 | E. coli - derived recombinant Human PRKAB2 (Lys17-Lys260). |
| 靶标 | AMPK subunit beta-2,PRKAB2,5'-AMP-activated protein kinase subunit beta-2 |
| 纯化方式 | Purified by antigen affinity column. |
| Accession号 | O43741 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | 5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) is a ~30 kDa protein. Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
| Note | For research use only. |

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