

| 货号 | PTX19471 |
|---|---|
| 品牌 | ProteoGenix |
| 描述 |
Anti-NR1I2 Polyclonal Antibody (PTX19471) is a rabbit polyclonal antibody detecting NR1I2,SXR,PXR,Steroid and xenobiotic receptor,Orphan nuclear receptor PXR,Nuclear receptor subfamily 1 group I member 2,Pregnane X receptor,Orphan nuclear receptor PAR1 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
| 种属反应性 | Human |
| 应用 | ELISA, IHC, WB |
| 宿主 | Rabbit |
| 同种型 | IgG |
| 克隆类型 | Polyclonal |
| 免疫原 | E. coli - derived recombinant Human NR1I2 (Ser130-Ile431). |
| 靶标 | NR1I2,SXR,PXR,Steroid and xenobiotic receptor,Orphan nuclear receptor PXR,Nuclear receptor subfamily 1 group I member 2,Pregnane X receptor,Orphan nuclear receptor PAR1 |
| 纯化方式 | Purified by antigen affinity column. |
| Accession号 | O75469 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Nuclear receptor subfamily 1 group I member 2 (NR1I2) is a ~49 kDa protein. Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. Activated by a broad range of endogenous steroids (e.g. pregnenolone, progesterone) and xenobiotics, including the antibiotic rifampicin and certain plant-derived metabolites. Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation. Target genes include cytochrome P450 enzymes such as CYP3A4 and ATP-binding cassette transporters including ABCB1/MDR1. |
| Note | For research use only. |

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