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Anti-DDAH2 Polyclonal Antibody (PTX19477)

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概述
货号PTX19477
品牌ProteoGenix
描述
Anti-DDAH2 Polyclonal Antibody (PTX19477) is a rabbit polyclonal antibody detecting DDAH,Dimethylargininase-2,NG30,DDAHII,DDAH2,Protein G6a,N(G),N(G)-dimethylarginine dimethylaminohydrolase 2,S-phase protein,G6A,Dimethylarginine dimethylaminohydrolase 2,DDAH-2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human DDAH2 (Ala31-Leu265).
靶标DDAH,Dimethylargininase-2,NG30,DDAHII,DDAH2,Protein G6a,N(G),N(G)-dimethylarginine dimethylaminohydrolase 2,S-phase protein,G6A,Dimethylarginine dimethylaminohydrolase 2,DDAH-2
纯化方式Purified by antigen affinity column.
Accession号O95865
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Putative hydrolase DDAH2 is a ~29 kDa protein. Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS. In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase. Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein. Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS.

1. Hu, X. et al. (2011) Arteriosclerosis, thrombosis, and vascular biology 31, 1540-6. PMID: 21493890
2. Ragavan, VN. et al. (2023) Nature communications 14, 3392. PMID: 37296100
3. Huang, S. et al. (2021) Science signaling 14. PMID: 33850055
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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