Angiogenin is a ~16 kDa protein. Secreted ribonuclease that can either promote or restrict cell proliferation of target cells, depending on the context. Endocytosed in target cells via its receptor PLXNB2 and translocates to the cytoplasm or nucleus. Under stress conditions, localizes to the cytoplasm and promotes the assembly of stress granules (SGs): specifically cleaves a subset of tRNAs within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs), resulting in translation repression and inhibition of cell proliferation. tiRNas also prevent formation of apoptosome, thereby promoting cell survival. Preferentially cleaves RNAs between a pyrimidine and an adenosine residue, suggesting that it cleaves the anticodon loop of tRNA(Ala) (32-UUAGCAU-38) after positions 33 and 36. 1. Xu, ZP. et al. (2002) Biochemical and biophysical research communications 294, 287-92. PMID: 120517082. Saxena, SK. et al. (1992) The Journal of biological chemistry 267, 21982-6. PMID: 14005103. Yamasaki, S. et al. (2009) The Journal of cell biology 185, 35-42. PMID: 193328864. Emara, MM. et al. (2010) The Journal of biological chemistry 285, 10959-68. PMID: 201299166. Thiyagarajan, N. et al. (2012) Nature communications 3, 1121. PMID: 230476797. Pizzo, E. et al. (2013) Journal of cell science 126, 4308-19. PMID: 238436258. Shapiro, R. et al. (1986) Biochemistry 25, 3527-32. PMID: 24244969. Harper, JW. et al. (1988) Proceedings of the National Academy of Sciences of the United States of America 85, 7139-43. PMID: 245969710. Lee, FS. et al. (1989) Biochemical and biophysical research communications 161, 121-6. PMID: 2730651 | 
