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Anti-CYP17A1 Polyclonal Antibody (PTX19513)

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概述
货号PTX19513
品牌ProteoGenix
描述
Anti-CYP17A1 Polyclonal Antibody (PTX19513) is a rabbit polyclonal antibody detecting Steroid 17-alpha-hydroxylase/17,20 lyase,CYPXVII,Cytochrome P450 17A1,Cytochrome P450-C17,Steroid 17-alpha-monooxygenase,17-alpha-hydroxyprogesterone aldolase,CYP17A1,S17AH,Cytochrome P450c17,CYP17 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human CYP17A1 (Cys183-Thr508).
靶标Steroid 17-alpha-hydroxylase/17,20 lyase,CYPXVII,Cytochrome P450 17A1,Cytochrome P450-C17,Steroid 17-alpha-monooxygenase,17-alpha-hydroxyprogesterone aldolase,CYP17A1,S17AH,Cytochrome P450c17,CYP17
纯化方式Purified by antigen affinity column.
Accession号P05093
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione.

1. DeVore, NM. et al. (2012) Nature 482, 116-9. PMID: 22266943
2. Petrunak, EM. et al. (2014) The Journal of biological chemistry 289, 32952-64. PMID: 25301938
3. Yoshimoto, FK. et al. (2016) The Journal of biological chemistry 291, 17143-64. PMID: 27339894
4. Auchus, RJ. et al. (1998) The Journal of biological chemistry 273, 3158-65. PMID: 9452426
5. Lee, SG. et al. (2023) Journal of inorganic biochemistry 240, 112085. PMID: 36640554
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-CYP17A1 Polyclonal Antibody

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