

| 货号 | PTX19544 |
|---|---|
| 品牌 | ProteoGenix |
| 描述 |
Anti-CYP21A2 Polyclonal Antibody (PTX19544) is a rabbit polyclonal antibody detecting CYP21,CYP21B,Cytochrome P450 21,Cytochrome P450-C21B,Cytochrome P450-C21,Cytochrome P450 XXI,21-OHase,Steroid 21-hydroxylase,Cytochrome P-450c21,CYP21A2 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
| 种属反应性 | Human |
| 应用 | ELISA, IHC, WB |
| 宿主 | Rabbit |
| 同种型 | IgG |
| 克隆类型 | Polyclonal |
| 免疫原 | E. coli - derived recombinant Human CYP21A2 (Leu107-Gly390). |
| 靶标 | CYP21,CYP21B,Cytochrome P450 21,Cytochrome P450-C21B,Cytochrome P450-C21,Cytochrome P450 XXI,21-OHase,Steroid 21-hydroxylase,Cytochrome P-450c21,CYP21A2 |
| 纯化方式 | Purified by antigen affinity column. |
| Accession号 | P08686 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Steroid 21-hydroxylase (CYP21A2) is a ~56 kDa protein. A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). 1. Tajima, T. et al. (1999) Gene therapy 6, 1898-903. PMID: 10602386 2. Grischuk, Y. et al. (2006) The Journal of clinical endocrinology and metabolism 91, 4976-80. PMID: 16984992 3. Concolino, P. et al. (2012) Metabolism: clinical and experimental 61, 519-24. PMID: 22014889 4. Pallan, PS. et al. (2015) The Journal of biological chemistry 290, 13128-43. PMID: 25855791 5. de Paula Michelatto, D. et al. (2016) International journal of endocrinology 2016, 4209670. PMID: 27721825 |
| Note | For research use only. |

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