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Anti-UCHL1 Polyclonal Antibody (PTX18699)

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概述
货号PTX18699
品牌ProteoGenix
描述
Anti-UCHL1 Polyclonal Antibody (PTX18699) is a rabbit polyclonal antibody detecting UCH-L1,PGP 9.5,UCHL1,Ubiquitin carboxyl-terminal hydrolase isozyme L1,Ubiquitin thioesterase L1,Neuron cytoplasmic protein 9.5,PGP9.5 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human UCHL1 (Gln2-Ala223).
靶标UCH-L1,PGP 9.5,UCHL1,Ubiquitin carboxyl-terminal hydrolase isozyme L1,Ubiquitin thioesterase L1,Neuron cytoplasmic protein 9.5,PGP9.5
纯化方式Purified by antigen affinity column.
Accession号P09936
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) is a ~24 kDa protein. Deubiquitinase that plays a role in the regulation of several processes such as maintenance of synaptic function, cardiac function, inflammatory response or osteoclastogenesis. Abrogates the ubiquitination of multiple proteins including WWTR1/TAZ, EGFR, HIF1A and beta-site amyloid precursor protein cleaving enzyme 1/BACE1. In addition, recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin to maintain a stable pool of monoubiquitin that is a key requirement for the ubiquitin-proteasome and the autophagy-lysosome pathways. Regulates amyloid precursor protein/APP processing by promoting BACE1 degradation resulting in decreased amyloid beta production. Plays a role in the immune response by regulating the ability of MHC I molecules to reach cross-presentation compartments competent for generating Ag-MHC I complexes.

1. Zhang, M. et al. (2012) Journal of neurochemistry 120, 1129-38. PMID: 22212137
2. Bilguvar, K. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 3489-94. PMID: 23359680
3. Goto, Y. et al. (2015) Nature communications 6, 6153. PMID: 25615526
4. Liu, Y. et al. (2002) Cell 111, 209-18. PMID: 12408865
5. Larsen, CN. et al. (1996) Biochemistry 35, 6735-44. PMID: 8639624
6. Leroy, E. et al. (1998) Nature 395, 451-2. PMID: 9774100
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-UCHL1 Polyclonal Antibody

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