Affinity Purified — Minimal background and high purity for reliable results.
Multi-Application — Validated across multiple applications.
种属反应性
Human
应用
ELISA, IHC, WB
宿主
Rabbit
克隆类型
Polyclonal
同种型
IgG
免疫原
E. coli - derived recombinant Human CD121a/IL1R1 (Asp21-Ile109).
靶标
IL-1RT1,IL-1R-alpha,mIL-1R1,CD121a,IL-1R-1,sIL-1RI,IL1RT1,IL1R1,sIL-1R1,IL1R,CD121 antigen-like family member A,Interleukin-1 receptor type I,Interleukin-1 receptor alpha,mIL-1RI,IL1RA,IL-1RT-1,Interleukin-1 receptor type 1,p80
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Interleukin-1 receptor type 1 (CD121a/IL1R1) is a ~65 kDa protein. Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.
1. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091
2. Wang, Y. et al. (2023) Immunity 56, 1485-1501.e7. PMID: 37315560
3. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850
