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Anti-IDO1 Polyclonal Antibody (PTX19587)

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概述
货号PTX19587
品牌ProteoGenix
描述
Anti-IDO1 Polyclonal Antibody (PTX19587) is a rabbit polyclonal antibody detecting INDO,IDO1,Indoleamine-pyrrole 2,3-dioxygenase,Indoleamine 2,3-dioxygenase 1,IDO-1,IDO in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human IDO1 (Met1-Gly403).
靶标INDO,IDO1,Indoleamine-pyrrole 2,3-dioxygenase,Indoleamine 2,3-dioxygenase 1,IDO-1,IDO
纯化方式Purified by antigen affinity column.
Accession号P14902
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Indoleamine 2,3-dioxygenase 1 (IDO1) is a ~45 kDa protein. Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan.

1. Metz, R. et al. (2007) Cancer research 67, 7082-7. PMID: 17671174
2. Yuasa, HJ. et al. (2007) Journal of molecular evolution 65, 705-14. PMID: 18026683
3. van Baren, N. et al. (2015) Frontiers in immunology 6, 34. PMID: 25691885
4. Uyttenhove, C. et al. (2003) Nature medicine 9, 1269-74. PMID: 14502282
5. Munn, DH. et al. (2013) Trends in immunology 34, 137-43. PMID: 23103127
6. Schmidt, SV. et al. (2014) Frontiers in immunology 5, 384. PMID: 25157255
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-IDO1 Polyclonal Antibody

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