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Anti-ATP2A2 Polyclonal Antibody (PTX19598)

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概述
货号PTX19598
品牌ProteoGenix
描述
Anti-ATP2A2 Polyclonal Antibody (PTX19598) is a rabbit polyclonal antibody detecting SERCA2,Calcium pump 2,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,ATP2B,SR Ca(2+)-ATPase 2,Calcium-transporting ATPase sarcoplasmic reticulum type,slow twitch skeletal muscle isoform,ATP2A2,Endoplasmic reticulum class 1/2 Ca(2+) ATPase in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human ATP2A2 (Ile315-Met756).
靶标SERCA2,Calcium pump 2,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,ATP2B,SR Ca(2+)-ATPase 2,Calcium-transporting ATPase sarcoplasmic reticulum type,slow twitch skeletal muscle isoform,ATP2A2,Endoplasmic reticulum class 1/2 Ca(2+) ATPase
纯化方式Purified by antigen affinity column.
Accession号P16615
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) is a ~114 kDa protein. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes. In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis.

1. Dhitavat, J. et al. (2003) The Journal of investigative dermatology 120, 229-32. PMID: 12542527
2. Dally, S. et al. (2006) The Biochemical journal 395, 249-58. PMID: 16402920
3. Zhao, YG. et al. (2017) Molecular cell 67, 974-989.e6. PMID: 28890335
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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