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Anti-CD106/VCAM1 Polyclonal Antibody (PTX19610)

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概述
货号PTX19610
品牌ProteoGenix
描述
Anti-CD106/VCAM1 Polyclonal Antibody (PTX19610) is a rabbit polyclonal antibody detecting Vascular cell adhesion protein 1,VCAM1,CD106,INCAM-100,V-CAM 1,VCAM-1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CD106/VCAM1 (Phe25-Glu698).
靶标Vascular cell adhesion protein 1,VCAM1,CD106,INCAM-100,V-CAM 1,VCAM-1
纯化方式Purified by antigen affinity column.
Accession号P19320
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Vascular cell adhesion protein 1 (CD106/VCAM1) is a ~81 kDa protein. Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation.

1. Li, Y. et al. (2020) Journal of molecular cell biology 12, 190-201. PMID: 31310649
2. Taooka, Y. et al. (1999) The Journal of cell biology 145, 413-20. PMID: 10209034
3. Marchese, ME. et al. (2012) Biochemistry 51, 8235-46. PMID: 22970700
4. Pinho, S. et al. (2022) Nature cell biology 24, 290-298. PMID: 35210567
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-CD106/VCAM1 Polyclonal Antibody

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