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Anti-FPR1 Polyclonal Antibody (PTX19615)

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概述
货号PTX19615
品牌ProteoGenix
描述
Anti-FPR1 Polyclonal Antibody (PTX19615) is a rabbit polyclonal antibody detecting fMet-Leu-Phe receptor,fMLP receptor,N-formyl peptide receptor,FPR,FPR1,N-formylpeptide chemoattractant receptor in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human FPR1 (Arg163-Val242).
靶标fMet-Leu-Phe receptor,fMLP receptor,N-formyl peptide receptor,FPR,FPR1,N-formylpeptide chemoattractant receptor
纯化方式Purified by antigen affinity column.
Accession号P21462
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

N-formyl peptide receptor 1 (FPR1) is a ~38 kDa protein. Pattern recognition G-protein coupled receptor (PRR/GPCR) involved in innate recognition of N-formyl-methionyl peptides derived from invading microbes and host mitochondria as pathogen- and damage-associated molecular patterns (PAMPs and DAMPs). Functions as a sensor of PAMPs and DAMPs released upon microbial infection or tissue damage, triggering immune cell activation and chemotaxis to eliminate pathogens and restore tissue homeostasis. Peptide binding leads to conformational changes coupled to heterotrimeric G(i) protein signaling. Upon GDP to GTP conversion, G(i)-alpha subunit dissociates from G-beta and G-gamma subunits. Free G(i)-alpha subunit inhibits cyclic adenylate cyclase and cAMP synthesis whereas the G-beta and G-gamma dimer activates downstream phospholipase C-beta and phosphoinositide 3-kinase signaling cascades leading to Ca(2+) influx.

1. Cooray, SN. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 18232-7. PMID: 24108355
2. Bufe, B. et al. (2015) The Journal of biological chemistry 290, 7369-87. PMID: 25605714
3. Zhuang, Y. et al. (2022) Nature communications 13, 1054. PMID: 35217703
4. Chen, G. et al. (2022) Nature communications 13, 5232. PMID: 36064945
5. Maestes, DC. et al. (1999) The Journal of biological chemistry 274, 29791-5. PMID: 10514456
6. Postma, B. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 6994-7001. PMID: 15153520
7. Murphy, PM. et al. (1991) The Journal of biological chemistry 266, 12560-7. PMID: 1712023
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-FPR1 Polyclonal Antibody

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