| 背景 | Cyclin-dependent kinase 2 (CDK2) is a ~33 kDa protein. Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, SUV39H1, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs). 2. Luciani, MG. et al. (2000) Journal of molecular biology 300, 503-18. PMID: 108843473. Zhao, J. et al. (2000) Genes & development 14, 2283-97. PMID: 109953864. Ma, T. et al. (2000) Genes & development 14, 2298-313. PMID: 109953876. Garrett, S. et al. (2001) Molecular and cellular biology 21, 88-99. PMID: 111131847. Terret, ME. et al. (2003) Development (Cambridge, England) 130, 5169-77. PMID: 129444319. Brown, NR. et al. (2007) Cell cycle (Georgetown, Tex.) 6, 1350-9. PMID: 1749553110. Hydbring, P. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 58-63. PMID: 19966300 |
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